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Issue 3, 2010
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Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition

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Abstract

The copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) is the premier example of a click reaction. The reaction is modular, reliable and easy to perform, providing easy access to molecular diversity. The majority of reported applications of the reaction employ the 1,2,3-triazole as a stable linkage to connect two chemical/biological components, while the potential for metal coordination of the heterocycle itself has received much less attention. In fact, 1,4-functionalized 1,2,3-triazoles are versatile ligands offering several donor sites for metal coordination, including N3, N2 and C5. In this article, we summarize the areas in which the CuAAC has been applied to the synthesis of novel triazole-containing ligands for transition metals.

Graphical abstract: Metal chelating systems synthesized using the copper(i) catalyzed azide-alkyne cycloaddition

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Publication details

The article was received on 01 Jul 2009, accepted on 16 Oct 2009 and first published on 23 Nov 2009


Article type: Perspective
DOI: 10.1039/B912608B
Citation: Dalton Trans., 2010,39, 675-696
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    Metal chelating systems synthesized using the copper(I) catalyzed azide-alkyne cycloaddition

    H. Struthers, T. L. Mindt and R. Schibli, Dalton Trans., 2010, 39, 675
    DOI: 10.1039/B912608B

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