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Issue 4, 2010
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Cu-free click cycloaddition reactions in chemical biology

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Abstract

Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems—in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.

Graphical abstract: Cu-free click cycloaddition reactions in chemical biology

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Publication details

The article was received on 08 Oct 2009 and first published on 19 Jan 2010


Article type: Tutorial Review
DOI: 10.1039/B901970G
Citation: Chem. Soc. Rev., 2010,39, 1272-1279
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    Cu-free click cycloaddition reactions in chemical biology

    J. C. Jewett and C. R. Bertozzi, Chem. Soc. Rev., 2010, 39, 1272
    DOI: 10.1039/B901970G

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