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Issue 3, 2010
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Nanofluidics in chemical analysis

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Nanofluidic architectures and devices have already had a major impact on forefront problems in chemical analysis, especially those involving mass-limited samples. This critical review begins with a discussion of the fundamental flow physics that distinguishes nanoscale structures from their larger microscale analogs, especially the concentration polarization that develops at nanofluidic/microfluidic interfaces. Chemical manipulations in nanopores include nanopore-mediated separations, microsensors, especially resistive-pulse sensing of biomacromolecules, fluidic circuit analogs and single molecule measurements. Coupling nanofluidic structures to three-dimensional microfluidic networks is especially powerful and results in applications in sample preconcentration, nanofluidic injection/collection and fast diffusive mixing (160 references).

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The article was received on 03 Jul 2009 and first published on 23 Oct 2009

Article type: Critical Review
DOI: 10.1039/B900409M
Citation: Chem. Soc. Rev., 2010,39, 1060-1072
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    Nanofluidics in chemical analysis

    A. Piruska, M. Gong, J. V. Sweedler and P. W. Bohn, Chem. Soc. Rev., 2010, 39, 1060
    DOI: 10.1039/B900409M

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