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Issue 3, 2010
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DNA manipulation, sorting, and mapping in nanofluidic systems

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Abstract

Fluidic systems with nanometre length scales enable sensitive analysis of DNA molecules. Nanofluidic systems have been used to probe conformational, dynamic, and entropic properties of DNA molecules, to rapidly sort DNA molecules based on length dependent interactions with their confining environment, and for determining the spatial location of genetic information along long DNA molecules. In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references).

Graphical abstract: DNA manipulation, sorting, and mapping in nanofluidic systems

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Publication details

The article was received on 17 Aug 2009 and first published on 12 Jan 2010


Article type: Critical Review
DOI: 10.1039/B820266B
Citation: Chem. Soc. Rev., 2010,39, 1133-1152
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    DNA manipulation, sorting, and mapping in nanofluidic systems

    S. L. Levy and H. G. Craighead, Chem. Soc. Rev., 2010, 39, 1133
    DOI: 10.1039/B820266B

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