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Issue 4, 2010
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Click chemistry generates privileged CH hydrogen-bonding triazoles: the latest addition to anion supramolecular chemistry

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Abstract

The supramolecular chemistry of anions provides a means to sense and manipulate anions in their many chemical and biological roles. For this purpose, Click chemistry facilitated the synthetic creation of new receptors and thus, an opportunity to aid in the recent re-examination of CH⋯anion hydrogen bonding. This tutorial review will focus on the privileged C–H hydrogen bond donor of the 1,2,3-triazole ring systems as elucidated from anion-binding studies with macrocyclic triazolophanes and other receptors. Triazolophanes are shape-persistent and planar macrocycles that direct four triazole and four phenylene CH groups into a 3.7 Å cavity. They display strong (log K(Cl) = 7), size-dependent halide binding (Cl > BrF ≫ I) and a rich set of binding equilibria. For instance, the too large iodide (4.4 Å) can be sandwiched between two pyridyl-based triazolophanes with extreme positive cooperativity. Computational studies verify the triazole's hydrogen bond strength indicating it approaches the traditional NH donors from pyrrole. These examples, those of transport, sensing (e.g., ion-selective electrodes), templation, and versatile synthesis herald the use of triazoles in anion-receptor chemistry.

Graphical abstract: Click chemistry generates privileged CH hydrogen-bonding triazoles: the latest addition to anion supramolecular chemistry

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Publication details

The article was received on 18 Sep 2009 and first published on 24 Feb 2010


Article type: Tutorial Review
DOI: 10.1039/B818033B
Citation: Chem. Soc. Rev., 2010,39, 1262-1271
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    Click chemistry generates privileged CH hydrogen-bonding triazoles: the latest addition to anion supramolecular chemistry

    Y. Hua and A. H. Flood, Chem. Soc. Rev., 2010, 39, 1262
    DOI: 10.1039/B818033B

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