Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

Devdutt Chaturvedi; Abhishek Goswami; Partha Pratim Saikia; Nabin C. Barua; Paruchuri G. Rao

doi:10.1039/B816679J

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Chemical Society Reviews

Issue 2, 2010

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Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

Devdutt Chaturvedi , Abhishek Goswami , Partha Pratim Saikia , Nabin C. Barua and Paruchuri G. Rao

Chem. Soc. Rev., 2010, 39, 435-454

DOI: 10.1039/B816679J
Received 03 Feb 2009, First published on the web 24 Aug 2009

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In this tutorial review, an effort towards presentation of a comprehensive account of the recent developments on various kinds of artemisinin derivatives including artemisinin dimers, trimers and tetramers has been made and their efficacy towards malaria parasites and different cancer cells lines was compared with that of artemisinins, and various other anti-malarial and anti-cancer drugs. It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.

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Devdutt Chaturvedi
Abhishek Goswami
Partha Pratim Saikia
Nabin C. Barua
Paruchuri G. Rao

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Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

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