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Issue 11, 2010
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Recent advances in the use of temporary silicon tethers in metal-mediated reactions

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Abstract

This tutorial review describes the use of temporary silicon tethers in metal-mediated organic reactions, a strategy which although well-established in traditional organic synthesis is still a blossoming field in the organometallic arena. The benefits of silicon-tethering are manifold: the reactivity, selectivity, and efficiency of organometallic processes can all be dramatically enhanced, often with unique regio- and stereochemical outcomes compared to the analogous intermolecular transformations. In addition, the residual silicon functionality can undergo a wide range of chemistry subsequent to the tethered reaction, creating further synthetic opportunities.

Graphical abstract: Recent advances in the use of temporary silicon tethers in metal-mediated reactions

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Publication details

The article was received on 11 Jun 2010 and first published on 14 Sep 2010


Article type: Tutorial Review
DOI: 10.1039/C0CS00007H
Citation: Chem. Soc. Rev., 2010,39, 4114-4129
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    Recent advances in the use of temporary silicon tethers in metal-mediated reactions

    S. Bracegirdle and E. A. Anderson, Chem. Soc. Rev., 2010, 39, 4114
    DOI: 10.1039/C0CS00007H

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