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Issue 34, 2010
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Microelectrode investigation of neuroneal ageing from a single identified neurone

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Abstract

Microelectrode amperometry is uniquely suited for characterising the dynamics of neurotransmitter release, as it offers unparalleled spatial and temporal resolution. We have used carbon fibre microelectrodes to study release of the monoamine neurotransmitter serotonin (5-HT) and the gaseous transmitter nitric oxide (NO) in intact central nervous system of the water snail, Lymnaea stagnalis. Analysis of spontaneous vesicular release of 5-HT and depolarisation-induced release of NO reveals significant differences with ageing that may be associated with changes in protein structure and function.

Graphical abstract: Microelectrode investigation of neuroneal ageing from a single identified neurone

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Publication details

The article was received on 21 Apr 2010, accepted on 14 Jun 2010 and first published on 12 Jul 2010


Article type: Paper
DOI: 10.1039/C0CP00310G
Citation: Phys. Chem. Chem. Phys., 2010,12, 10065-10072
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    Microelectrode investigation of neuroneal ageing from a single identified neurone

    B. A. Patel, M. Arundell, K. H. Parker, M. S. Yeoman and D. O'Hare, Phys. Chem. Chem. Phys., 2010, 12, 10065
    DOI: 10.1039/C0CP00310G

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