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Issue 31, 2010
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Valence bond all the way: From the degenerate H-exchange to cytochrome P450

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Abstract

This is a personalized Perspective on the development of a valence bond (VB) view of chemical reactivity (J. Am. Chem. Soc., 1981, 103, 3692) as a LEGO process whereby one constructs “reactivity objects”, such as barriers, transition states, and reaction intermediates from VB building blocks, and thereby understands and predicts chemical reactivity in a unified manner. In so doing, I have tried to give the reader a panoramic set of applications, from the simple H-exchange reaction all the way to alkane hydroxylation by cytochrome P450 (Prog. Phys. Org. Chem. 1985, 15, 197; Angew. Chem., Int. Ed., 1999, 38, 586).

Graphical abstract: Valence bond all the way: From the degenerate H-exchange to cytochrome P450

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Publication details

The article was received on 20 Jan 2010, accepted on 23 Apr 2010 and first published on 24 Jun 2010


Article type: Perspective
DOI: 10.1039/C001372M
Citation: Phys. Chem. Chem. Phys., 2010,12, 8706-8720
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    Valence bond all the way: From the degenerate H-exchange to cytochrome P450

    S. Shaik, Phys. Chem. Chem. Phys., 2010, 12, 8706
    DOI: 10.1039/C001372M

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