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Issue 2, 2011
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A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis

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Abstract

In a new variation on the Fischer indole synthesis, readily available haloarenes are converted into a wide range of indoles in just two steps by halogen-magnesium exchange, quenching with di-tert-butyl azodicarboxylate, followed by reaction with ketones under acidic conditions.

Graphical abstract: A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis

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Publication details

The article was received on 08 Oct 2010, accepted on 01 Nov 2010, published on 22 Nov 2010 and first published online on 22 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC04306K
Citation: Chem. Commun., 2011,47, 788-790
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    A two step route to indoles from haloarenes—a versatile variation on the Fischer indole synthesis

    M. Inman and C. J. Moody, Chem. Commun., 2011, 47, 788
    DOI: 10.1039/C0CC04306K

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