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Issue 47, 2010
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Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

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Abstract

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)–poly(ethylene glycol) (oil phase), the surfactant n-octyl β-D-glucopyranoside, and the cosurfactant n-butanol.

Graphical abstract: Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

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Publication details

The article was received on 06 Oct 2010, accepted on 15 Oct 2010 and first published on 04 Nov 2010


Article type: Communication
DOI: 10.1039/C0CC04258G
Citation: Chem. Commun., 2010,46, 9034-9036
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    Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

    J. Ge, G. B. Jacobson, T. Lobovkina, K. Holmberg and R. N. Zare, Chem. Commun., 2010, 46, 9034
    DOI: 10.1039/C0CC04258G

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