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Issue 43, 2010
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Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography

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Abstract

Here we report the total synthesis of kaliotoxin by ‘one pot’ native chemical ligation of three synthetic peptides. A racemic mixture of D- and L-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P[1 with combining macron] that diffracted to atomic-resolution (0.95 Å), enabling the X-ray structure of kaliotoxin to be determined by direct methods.

Graphical abstract: Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography

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Publication details

The article was received on 10 Aug 2010, accepted on 06 Sep 2010 and first published on 28 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC03148H
Citation: Chem. Commun., 2010,46, 8174-8176
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    Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography

    B. L. Pentelute, K. Mandal, Z. P. Gates, M. R. Sawaya, T. O. Yeates and S. B. H. Kent, Chem. Commun., 2010, 46, 8174
    DOI: 10.1039/C0CC03148H

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