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Issue 42, 2010
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Tetrazinetrans-cyclooctene ligation for the rapid construction of 18F labeled probes

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Abstract

A radiolabeling method for bioconjugation based on the Diels–Alder reaction between 3,6-diaryl-s-tetrazines and an 18F-labeled trans-cyclooctene is described. The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations.

Graphical abstract: Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes

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Publication details

The article was received on 05 Aug 2010, accepted on 06 Sep 2010 and first published on 22 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC03078C
Citation: Chem. Commun., 2010,46, 8043-8045
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    Tetrazinetrans-cyclooctene ligation for the rapid construction of 18F labeled probes

    Z. Li, H. Cai, M. Hassink, M. L. Blackman, R. C. D. Brown, P. S. Conti and J. M. Fox, Chem. Commun., 2010, 46, 8043
    DOI: 10.1039/C0CC03078C

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