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The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer

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a
Department of Chemistry, The University of Iowa, Iowa City, IA, USA
E-mail: amnon-kohen@uiowa.edu;
Fax: +1 319 335 1270 ;
Tel: +1 319 335 0234
b
Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, piso 3, C1428EHA Buenos Aires, Argentina
c
Department of Chemistry, Pennsylvania State University, University Park, PA, USA
Chem. Commun., 2010,46, 8974-8976

DOI: 10.1039/C0CC02988B
Received 02 Aug 2010, Accepted 28 Sep 2010
First published online 25 Oct 2010
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