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Issue 47, 2010
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The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer

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Abstract

Comparison of the nature of hydride transfer in wild-type and active site mutant (I14A) of dihydrofolate reductase suggests that the size of this side chain at position 14 modulates H-tunneling.

Graphical abstract: The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer

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Publication details

The article was received on 02 Aug 2010, accepted on 28 Sep 2010 and first published on 25 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC02988B
Citation: Chem. Commun., 2010,46, 8974-8976
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    The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer

    V. Stojković, L. L. Perissinotti, J. Lee, S. J. Benkovic and A. Kohen, Chem. Commun., 2010, 46, 8974
    DOI: 10.1039/C0CC02988B

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