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Issue 46, 2010
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Computational design of orthogonal nucleoside kinases

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Abstract

We report the computational enzyme design of an orthogonal nucleoside analog kinase for 3′-deoxythymidine. The best kinase variant shows an 8500-fold change in substrate specificity, resulting from a 4.6-fold gain in catalytic efficiency for the nucleoside analog and a 2000-fold decline for the native substrate thymidine.

Graphical abstract: Computational design of orthogonal nucleoside kinases

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Publication details

The article was received on 01 Aug 2010, accepted on 29 Sep 2010 and first published on 19 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC02961K
Citation: Chem. Commun., 2010,46, 8803-8805
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    Computational design of orthogonal nucleoside kinases

    L. Liu, P. Murphy, D. Baker and S. Lutz, Chem. Commun., 2010, 46, 8803
    DOI: 10.1039/C0CC02961K

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