Jump to main content
Jump to site search

Issue 41, 2010
Previous Article Next Article

Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet–Spengler-type cyclization sequence

Author affiliations

Abstract

We have combined the biocatalytic desymmetrization of 3,4-cis-substituted meso-pyrrolidines with an Ugi-type multicomponent reaction followed in situ by a Pictet–Spengler-type cyclization reaction sequence for the rapid asymmetric synthesis of alkaloid-like polycyclic compounds.

Graphical abstract: Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet–Spengler-type cyclization sequence

Back to tab navigation

Supplementary files

Publication details

The article was received on 31 Jul 2010, accepted on 07 Sep 2010 and first published on 27 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02938F
Citation: Chem. Commun., 2010,46, 7706-7708
  •   Request permissions

    Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet–Spengler-type cyclization sequence

    A. Znabet, J. Zonneveld, E. Janssen, F. J. J. De Kanter, M. Helliwell, N. J. Turner, E. Ruijter and R. V. A. Orru, Chem. Commun., 2010, 46, 7706
    DOI: 10.1039/C0CC02938F

Search articles by author

Spotlight

Advertisements