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Issue 41, 2010
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Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4

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Abstract

A helical tyrosine-sulfated epitope in CCR5 that is recognized by the human immunodeficiency virus type-1 envelope glycoprotein gp120 in its CD4-induced conformation can be mimicked structurally by a cyclic β-hairpin peptide containing two sulfated tyrosine residues at positions i and i + 2 along one β-strand.

Graphical abstract: Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4

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Publication details

The article was received on 30 Jul 2010, accepted on 16 Aug 2010 and first published on 08 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02913K
Citation: Chem. Commun., 2010,46, 7754-7756
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    Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4

    M. Seitz, P. Rusert, K. Moehle, A. Trkola and J. A. Robinson, Chem. Commun., 2010, 46, 7754
    DOI: 10.1039/C0CC02913K

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