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Issue 40, 2010
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α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

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Abstract

Transketolase mutants have been identified that accept aromatic acceptors with good stereoselectivities, in particular benzaldehyde for which the wild type enzyme showed no activity.

Graphical abstract: α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

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Publication details

The article was received on 30 Jul 2010, accepted on 25 Aug 2010 and first published on 10 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02911D
Citation: Chem. Commun., 2010,46, 7608-7610
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    α,α′-Dihydroxyketone formation using aromatic and heteroaromatic aldehydes with evolved transketolase enzymes

    J. L. Galman, D. Steadman, S. Bacon, P. Morris, M. E. B. Smith, J. M. Ward, P. A. Dalby and H. C. Hailes, Chem. Commun., 2010, 46, 7608
    DOI: 10.1039/C0CC02911D

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