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Issue 46, 2010
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Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A

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Abstract

The solid phase total synthesis of the marine cyanobacterial Ahp-cyclodepsipeptide Symplocamide A is reported as a model for a general route for the synthesis of tailor-made non-covalent serine protease inhibitors.

Graphical abstract: Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A

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Publication details

The article was received on 29 Jul 2010, accepted on 27 Sep 2010 and first published on 22 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC02889D
Citation: Chem. Commun., 2010,46, 8857-8859
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    Solid phase total synthesis of the 3-amino-6-hydroxy-2-piperidone (Ahp) cyclodepsipeptide and protease inhibitor Symplocamide A

    S. C. Stolze, M. Meltzer, M. Ehrmann and M. Kaiser, Chem. Commun., 2010, 46, 8857
    DOI: 10.1039/C0CC02889D

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