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Issue 42, 2010
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Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

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Abstract

An iridium catalysed oxidation was coupled concurrently to an asymmetric biocatalytic reduction in one-pot; thus it was shown for the first time that iridium- and alcohol dehydrogenase-catalysed redox reactions are compatible. As a model system racemic chlorohydrins were transformed to enantioenriched chlorohydrins via an oxidation–asymmetric reduction sequence.

Graphical abstract: Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

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Publication details

The article was received on 26 Jul 2010, accepted on 07 Sep 2010 and first published on 27 Sep 2010


Article type: Communication
DOI: 10.1039/C0CC02813D
Citation: Chem. Commun., 2010,46, 8046-8048
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    Simultaneous iridium catalysed oxidation and enzymatic reduction employing orthogonal reagents

    F. G. Mutti, A. Orthaber, J. H. Schrittwieser, J. G. D. Vries, R. Pietschnig and W. Kroutil, Chem. Commun., 2010, 46, 8046
    DOI: 10.1039/C0CC02813D

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