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Issue 46, 2010
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Exo/endo selectivity-control in Lewis-acid catalyzed tandem heterocyclization/formal [4+3] cycloaddition: synthesis of polyheterocycles from 2-(1-alkynyl)-2-alken-1-ones and 1,3-diphenylisobenzofuran

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Abstract

A novel catalytic exo/endo selectivity-controllable tandem heterocyclization/formal [4+3] cycloaddition was developed, which provides rapid, efficient and stereoselective access to highly fused polyheterocycles from readily available 2-(1-alkynyl)-2-alken-1-ones and 1,3-diphenylisobenzofuran under mild conditions.

Graphical abstract: Exo/endo selectivity-control in Lewis-acid catalyzed tandem heterocyclization/formal [4+3] cycloaddition: synthesis of polyheterocycles from 2-(1-alkynyl)-2-alken-1-ones and 1,3-diphenylisobenzofuran

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Publication details

The article was received on 24 Jul 2010, accepted on 06 Oct 2010 and first published on 21 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC02778B
Citation: Chem. Commun., 2010,46, 8764-8766
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    Exo/endo selectivity-control in Lewis-acid catalyzed tandem heterocyclization/formal [4+3] cycloaddition: synthesis of polyheterocycles from 2-(1-alkynyl)-2-alken-1-ones and 1,3-diphenylisobenzofuran

    H. Gao, X. Wu and J. Zhang, Chem. Commun., 2010, 46, 8764
    DOI: 10.1039/C0CC02778B

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