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Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency

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a
Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Box 100245, Gainesville, USA
E-mail: rmckenna@ufl.edu;
Fax: +1 352 392-3422 ;
Tel: +1 352 392-5696
b
Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, I-50019 Sesto Fiorentino (Firenze), Italy
E-mail: claudiu.supuran@unifi.it
Chem. Commun., 2010,46, 8371-8373

DOI: 10.1039/C0CC02707C
Received 21 Jul 2010, Accepted 20 Sep 2010
First published online 05 Oct 2010
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