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Issue 46, 2010
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Cleavage specificities of the brother and sister proteases Lys-C and Lys-N

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Abstract

Understanding of protease specificity is essential in proteomics strategies to correctly compare peptide fragmentation spectra with spectra predicted from data extracted from sequence databases. Here we evaluate the specificities of two proteolytic enzymes Lys-C and Lys-N, which cleave peptide-bonds at, respectively, the C- and N-terminal side of a lysine residue.

Graphical abstract: Cleavage specificities of the brother and sister proteases Lys-C and Lys-N

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Publication details

The article was received on 12 Jul 2010, accepted on 22 Sep 2010 and first published on 18 Oct 2010


Article type: Communication
DOI: 10.1039/C0CC02523B
Citation: Chem. Commun., 2010,46, 8827-8829
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    Cleavage specificities of the brother and sister proteases Lys-C and Lys-N

    R. Raijmakers, P. Neerincx, S. Mohammed and A. J. R. Heck, Chem. Commun., 2010, 46, 8827
    DOI: 10.1039/C0CC02523B

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