Issue 1, 2011
From the journal:

Chemical Communications

Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes†‡

Nadine Kuhla  and  Frank Glorius*a  

* Corresponding authors

a Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany
E-mail: glorius@uni-muenster.de
Fax: +49 251 8333202
Tel: +49 251 8333248

Abstract

The N-heterocyclic carbene-catalyzed coupling of several aldehydes with paraformaldehyde is reported, directly providing the corresponding valuable hydroxymethyl ketones. Results of first mechanistic experiments for this remarkably selective transformation are also provided.

Graphical abstract: Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes

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Article information

DOI
https://doi.org/10.1039/C0CC02416C
Article type
Communication
Submitted
07 Jul 2010
Accepted
13 Sep 2010
First published
01 Nov 2010

Chem. Commun., 2011,47, 573-575

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Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes

N. Kuhl and F. Glorius, Chem. Commun., 2011, 47, 573 DOI: 10.1039/C0CC02416C

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