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Issue 34, 2010
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Practical iron-catalyzed dehalogenation of aryl halides

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Abstract

An operationally simple iron-catalyzed hydrodehalogenation of aryl halides has been developed with 1 mol% Fe(acac)3 and commercial t-BuMgCl as reductant. The mild reaction conditions (THF, 0 °C, 1.5 h) effect rapid chemoselective dehalogenation of (hetero)aryl halides (I, Br, Cl) and tolerate F, Cl, OR, SR, CN, CO2R, and vinyl groups.

Graphical abstract: Practical iron-catalyzed dehalogenation of aryl halides

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Publication details

The article was received on 20 Jun 2010, accepted on 12 Jul 2010 and first published on 09 Aug 2010


Article type: Communication
DOI: 10.1039/C0CC01980A
Citation: Chem. Commun., 2010,46, 6350-6352
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    Practical iron-catalyzed dehalogenation of aryl halides

    W. M. Czaplik, S. Grupe, M. Mayer and A. J. V. Wangelin, Chem. Commun., 2010, 46, 6350
    DOI: 10.1039/C0CC01980A

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