Issue 37, 2010
From the journal:

Chemical Communications

9-Aminoacridinepeptide derivatives as versatile reporter systems for use in fluorescence lifetime assays†

Beatrice A. Maltman,a   Colin J. Dunsmore,a   Sarah C. M. Couturier,b   Adina E. Tirnaveanu,a   Zoica Delbederi,b   R. Austin S. McMordie,b   Gregorio Naredo,a   Robert Ramagea  and  Graham Cotton*a  

* Corresponding authors

a Almac Sciences (Scotland), Elvingston Science Centre, By Gladsmuir, East Lothian, Scotland, UK
E-mail: Graham.Cotton@almacgroup.com
Fax: +44 (0)1875408151
Tel: +44 (0)2838395879

b Almac Sciences, Almac House, 20 Seagoe Industrial Estate, Craigavon, UK

Abstract

A novel long lifetime fluorescence reporter based on 9-aminoacridine was designed, the lifetime of which can be modulated in a defined manner when in proximity to a tryptophan residue enabling fluorescence lifetime based biochemical assays to be configured.

Graphical abstract: 9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays

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Article information

DOI
https://doi.org/10.1039/C0CC01901A
Article type
Communication
Submitted
15 Jun 2010
Accepted
28 Jul 2010
First published
23 Aug 2010

Chem. Commun., 2010,46, 6929-6931

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9-Aminoacridine peptide derivatives as versatile reporter systems for use in fluorescence lifetime assays

B. A. Maltman, C. J. Dunsmore, S. C. M. Couturier, A. E. Tirnaveanu, Z. Delbederi, R. A. S. McMordie, G. Naredo, R. Ramage and G. Cotton, Chem. Commun., 2010, 46, 6929 DOI: 10.1039/C0CC01901A

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