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Issue 35, 2010
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Enthalpically driven peptide stabilization by protective osmolytes

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Abstract

We determined the added enthalpic and entropic contributions of protective osmolytes to the folding of a model peptide into its native β-hairpin state. In contrast to entropically driven steric “crowding”, this study shows that sugars and polyols can act as protective osmolytes by primarily diminishing the unfavourable enthalpic contribution to folding.

Graphical abstract: Enthalpically driven peptide stabilization by protective osmolytes

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Publication details

The article was received on 06 Jun 2010, accepted on 05 Jul 2010 and first published on 26 Jul 2010


Article type: Communication
DOI: 10.1039/C0CC01763A
Citation: Chem. Commun., 2010,46, 6449-6451
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    Enthalpically driven peptide stabilization by protective osmolytes

    R. Politi and D. Harries, Chem. Commun., 2010, 46, 6449
    DOI: 10.1039/C0CC01763A

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