Issue 35, 2010
From the journal:

Chemical Communications

Enthalpically driven peptide stabilization by protective osmolytes†

Regina Politia  and  Daniel Harries*a  

* Corresponding authors

a Institute of Chemistry and The Fritz Haber Research Center, The Hebrew University, Jerusalem 91904, Israel
E-mail: daniel@fh.huji.ac.il
Fax: +972 2-6513742
Tel: +972 2-6585484

Abstract

We determined the added enthalpic and entropic contributions of protective osmolytes to the folding of a model peptide into its native β-hairpin state. In contrast to entropically driven steric “crowding”, this study shows that sugars and polyols can act as protective osmolytes by primarily diminishing the unfavourable enthalpic contribution to folding.

Graphical abstract: Enthalpically driven peptide stabilization by protective osmolytes

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Article information

DOI
https://doi.org/10.1039/C0CC01763A
Article type
Communication
Submitted
06 Jun 2010
Accepted
05 Jul 2010
First published
26 Jul 2010

Chem. Commun., 2010,46, 6449-6451

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Enthalpically driven peptide stabilization by protective osmolytes

R. Politi and D. Harries, Chem. Commun., 2010, 46, 6449 DOI: 10.1039/C0CC01763A

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