Issue 39, 2010
From the journal:

Chemical Communications

Golf ball-shaped PLGA microparticles with internal pores fabricated by simple O/W emulsion†

Mi Ri Kim,‡a   Seungwoo Lee,‡b   Jung-Ki Park*b  and  Kuk Young Cho*a  

* Corresponding authors

a Division of Advanced Materials Engineering and Institute for Rare Metals, Kongju National University, Cheonan, Chungnam, Korea
E-mail: kycho@kongju.ac.kr
Fax: +82-41-568 5776

b Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Engineering, Daejeon, Korea
E-mail: jungpark@kaist.ac.kr
Fax: +82-42-350-3910

Abstract

Simple oil-in-water emulsion led to structural complexity at both the surface and interior of the PLGA microsphere. A golf ball-like dimpled surface comes from the heteroaggregation of volatile nonsolvent colloid originating from the inside of the organic droplet as supported by in situ optical microscopy. The internal porous structure and encapsulation of hydrophobic agent inside the microparticle implies its potential application as a drug carrier.

Graphical abstract: Golf ball-shaped PLGA microparticles with internal pores fabricated by simple O/W emulsion

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Article information

DOI
https://doi.org/10.1039/C0CC01738H
Article type
Communication
Submitted
04 Jun 2010
Accepted
19 Aug 2010
First published
03 Sep 2010

Chem. Commun., 2010,46, 7433-7435

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Golf ball-shaped PLGA microparticles with internal pores fabricated by simple O/W emulsion

M. R. Kim, S. Lee, J. Park and K. Y. Cho, Chem. Commun., 2010, 46, 7433 DOI: 10.1039/C0CC01738H

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