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Issue 38, 2010
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Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

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Abstract

The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diubiquitin.

Graphical abstract: Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

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Publication details

The article was received on 13 May 2010, accepted on 05 Aug 2010 and first published on 25 Aug 2010


Article type: Communication
DOI: 10.1039/C0CC01382J
Citation: Chem. Commun., 2010,46, 7199-7201
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    Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

    R. Yang, K. K. Pasunooti, F. Li, X. Liu and C. Liu, Chem. Commun., 2010, 46, 7199
    DOI: 10.1039/C0CC01382J

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