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Issue 34, 2010
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Synthesis of MUC1–lipopeptide chimeras

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Abstract

An efficient method for the convergent assembly of MUC1–lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the TN and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam3CysSer were synthesised in high yields using a fragment-based condensation strategy.

Graphical abstract: Synthesis of MUC1–lipopeptide chimeras

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Publication details

The article was received on 12 May 2010, accepted on 25 Jun 2010 and first published on 28 Jul 2010


Article type: Communication
DOI: 10.1039/C0CC01360A
Citation: Chem. Commun., 2010,46, 6249-6251
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    Synthesis of MUC1–lipopeptide chimeras

    B. L. Wilkinson, L. R. Malins, C. K. Y. Chun and R. J. Payne, Chem. Commun., 2010, 46, 6249
    DOI: 10.1039/C0CC01360A

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