Issue 34, 2010
From the journal:

Chemical Communications

Synthesis of MUC1–lipopeptide chimeras†

Brendan L. Wilkinson,a   Lara R. Malins,a   Candy K. Y. Chuna  and  Richard J. Payne*a  

* Corresponding authors

a School of Chemistry, University of Sydney, NSW 2006, Australia
E-mail: richard.payne@chem.usyd.edu.au
Fax: (+61)-2-9351-3329
Tel: (+61)-2-9351-5877

Abstract

An efficient method for the convergent assembly of MUC1–lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the TN and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam3CysSer were synthesised in high yields using a fragment-based condensation strategy.

Graphical abstract: Synthesis of MUC1–lipopeptide chimeras

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Article information

DOI
https://doi.org/10.1039/C0CC01360A
Article type
Communication
Submitted
12 May 2010
Accepted
25 Jun 2010
First published
28 Jul 2010

Chem. Commun., 2010,46, 6249-6251

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Synthesis of MUC1–lipopeptide chimeras

B. L. Wilkinson, L. R. Malins, C. K. Y. Chun and R. J. Payne, Chem. Commun., 2010, 46, 6249 DOI: 10.1039/C0CC01360A

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