Jump to main content
Jump to site search

Issue 34, 2010
Previous Article Next Article

Benzoyl peroxide (BPO)-promoted oxidative trifluoromethylation of tertiary amines with trimethyl(trifluoromethyl)silane

Author affiliations

Abstract

The benzoyl peroxide (BPO)-promoted oxidative functionalization of tertiary amines under transition-metal-free reaction conditions was developed. Various 1-trifluoromethylated tetrahydroisoquinoline derivatives were prepared by employing this method. It constitutes the first example of direct trifluoromethylation of tertiary amines.

Graphical abstract: Benzoyl peroxide (BPO)-promoted oxidative trifluoromethylation of tertiary amines with trimethyl(trifluoromethyl)silane

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Apr 2010, accepted on 07 Jul 2010 and first published on 09 Aug 2010


Article type: Communication
DOI: 10.1039/C0CC01073A
Citation: Chem. Commun., 2010,46, 6285-6287
  •   Request permissions

    Benzoyl peroxide (BPO)-promoted oxidative trifluoromethylation of tertiary amines with trimethyl(trifluoromethyl)silane

    L. Chu and F. Qing, Chem. Commun., 2010, 46, 6285
    DOI: 10.1039/C0CC01073A

Search articles by author

Spotlight

Advertisements