Issue 36, 2010
From the journal:

Chemical Communications

HSA coated MnOnanoparticles with prominent MRI contrast for tumor imaging†

Jing Huang,‡ab   Jin Xie,‡ac   Kai Chen,a   Lihong Bu,ad   Seulki Lee,ac   Zhen Cheng,a   Xingguo Li*b  and  Xiaoyuan Chen*ac  

* Corresponding authors

a Department of Radiology and Bio-X Program, Stanford University, 1201 Welch Road P087, Stanford, USA
E-mail: shawn.chen@nih.gov

b Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China
E-mail: xgli@pku.edu.cn

c Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, USA

d Department of Radiology, The Fourth Hospital of Harbin Medical University, Heilongjiang, P.R. China

Abstract

We report in this Communication a facile, two-step surface modification strategy to achieve manganese oxide nanoparticles with prominent MRI T1 contrast. In a U87MG glioblastoma xenograft model, we confirmed that the particles can accumulate efficiently in tumor area to induce effective T1 signal alteration.

Graphical abstract: HSA coated MnO nanoparticles with prominent MRI contrast for tumor imaging

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Article information

DOI
https://doi.org/10.1039/C0CC01041C
Article type
Communication
Submitted
21 Apr 2010
Accepted
12 Jul 2010
First published
23 Aug 2010

Chem. Commun., 2010,46, 6684-6686

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HSA coated MnO nanoparticles with prominent MRI contrast for tumor imaging

J. Huang, J. Xie, K. Chen, L. Bu, S. Lee, Z. Cheng, X. Li and X. Chen, Chem. Commun., 2010, 46, 6684 DOI: 10.1039/C0CC01041C

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