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Issue 27, 2010
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Metal-catalyzed direct alkylations of (hetero)arenes via C–H bond cleavages with unactivated alkyl halides

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Abstract

Significant progress has been made in direct alkylations of (hetero)arenes with unactivated alkyl halides. Thus, C–H bond functionalizations were accomplished with β-hydrogen-containing alkyl halides in the presence of palladium, nickel or ruthenium catalysts under basic reaction conditions. A valuable asset of these methodologies is represented by their excellent regio- and chemoselectivities, along with remarkable mild reaction conditions, rendering this approach an attractive alternative to traditional alkylation strategies.

Graphical abstract: Metal-catalyzed direct alkylations of (hetero)arenes via C–H bond cleavages with unactivated alkyl halides

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Publication details

The article was received on 05 Apr 2010, accepted on 12 May 2010 and first published on 08 Jun 2010


Article type: Feature Article
DOI: 10.1039/C0CC00778A
Citation: Chem. Commun., 2010,46, 4866-4877
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    Metal-catalyzed direct alkylations of (hetero)arenes via C–H bond cleavages with unactivated alkyl halides

    L. Ackermann, Chem. Commun., 2010, 46, 4866
    DOI: 10.1039/C0CC00778A

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