Issue 22, 2010

Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

Abstract

Use of a bis-dithiane deprotection–tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.

Graphical abstract: Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

Supplementary files

Article information

Article type
Communication
Submitted
22 Feb 2010
Accepted
12 Apr 2010
First published
05 May 2010

Chem. Commun., 2010,46, 3967-3969

Synthesis of the bis-spiroacetal C25–C40 moiety of the antimitotic agent spirastrellolide B using a bis-dithiane deprotection/spiroacetalisation sequence

J. L. Chen and M. A. Brimble, Chem. Commun., 2010, 46, 3967 DOI: 10.1039/C0CC00056F

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