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Issue 14, 2010
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A flow-based synthesis of Imatinib: the API of Gleevec

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Abstract

A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.

Graphical abstract: A flow-based synthesis of Imatinib: the API of Gleevec

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Publication details

The article was received on 25 Jan 2010, accepted on 23 Feb 2010 and first published on 05 Mar 2010


Article type: Communication
DOI: 10.1039/C001550D
Citation: Chem. Commun., 2010,46, 2450-2452
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    A flow-based synthesis of Imatinib: the API of Gleevec

    M. D. Hopkin, I. R. Baxendale and S. V. Ley, Chem. Commun., 2010, 46, 2450
    DOI: 10.1039/C001550D

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