Issue 14, 2010
From the journal:

Chemical Communications

A flow-based synthesis of Imatinib: the API of Gleevec†

Mark D. Hopkin,a   Ian R. Baxendalea  and  Steven V. Ley*a  

* Corresponding authors

a Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk

Abstract

A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.

Graphical abstract: A flow-based synthesis of Imatinib: the API of Gleevec

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Article information

DOI
https://doi.org/10.1039/C001550D
Article type
Communication
Submitted
25 Jan 2010
Accepted
23 Feb 2010
First published
05 Mar 2010

Chem. Commun., 2010,46, 2450-2452

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A flow-based synthesis of Imatinib: the API of Gleevec

M. D. Hopkin, I. R. Baxendale and S. V. Ley, Chem. Commun., 2010, 46, 2450 DOI: 10.1039/C001550D

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