A flow-based synthesis of Imatinib: the API of Gleevec

Mark D. Hopkin; Ian R. Baxendale; Steven V. Ley

doi:10.1039/C001550D

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Chemical Communications

Issue 14, 2010

Urgent high quality communications from across the chemical sciences.

Impact Factor 6.169 100 Issues per Year Indexed in MEDLINE

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A flow-based synthesis of Imatinib: the API of Gleevec

Mark D. Hopkin,^a Ian R. Baxendale^a and Steven V. Ley*^a

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Innovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: svl1000@cam.ac.uk

Chem. Commun., 2010,46, 2450-2452

DOI: 10.1039/C001550D
Received 25 Jan 2010, Accepted 23 Feb 2010
First published online 05 Mar 2010

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Abstract
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A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation. An in-line solvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.

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Experimental and characterisation data for all compounds, detailed diagrams of flow reactor setup and sources of equipment and polymer-supported reagents
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