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Issue 16, 2010
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Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

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Abstract

The enantioselective three-component Michael addition–Pictet–Spengler sequence of β-ketoesters 1, α,β-unsaturated aldehydes 2 and tryptamines 4 represents a facile and rapid one-pot access to highly substituted indoloquinolizidines in moderate to excellent yields and good to excellent enantioselectivities.

Graphical abstract: Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

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Publication details

The article was received on 25 Jan 2010, accepted on 25 Feb 2010 and first published on 19 Mar 2010


Article type: Communication
DOI: 10.1039/C001512A
Citation: Chem. Commun., 2010,46, 2733-2735
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    Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition–Pictet–Spengler sequence

    X. Wu, X. Dai, L. Nie, H. Fang, J. Chen, Z. Ren, W. Cao and G. Zhao, Chem. Commun., 2010, 46, 2733
    DOI: 10.1039/C001512A

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