Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 17, 2010
Previous Article Next Article

An unnatural amino acid that mimics phosphotyrosine

Author affiliations

Abstract

By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (proteinprotein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and cell-proliferation experiments.

Graphical abstract: An unnatural amino acid that mimics phosphotyrosine

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 06 Jan 2010, accepted on 13 Feb 2010 and first published on 05 Mar 2010


Article type: Communication
DOI: 10.1039/C000283F
Citation: Chem. Commun., 2010,46, 2980-2982
  •   Request permissions

    An unnatural amino acid that mimics phosphotyrosine

    J. Ge, H. Wu and S. Q. Yao, Chem. Commun., 2010, 46, 2980
    DOI: 10.1039/C000283F

Search articles by author