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Issue 17, 2010
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An unnatural amino acid that mimics phosphotyrosine

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By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (proteinprotein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and cell-proliferation experiments.

Graphical abstract: An unnatural amino acid that mimics phosphotyrosine

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The article was received on 06 Jan 2010, accepted on 13 Feb 2010 and first published on 05 Mar 2010

Article type: Communication
DOI: 10.1039/C000283F
Citation: Chem. Commun., 2010,46, 2980-2982
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    An unnatural amino acid that mimics phosphotyrosine

    J. Ge, H. Wu and S. Q. Yao, Chem. Commun., 2010, 46, 2980
    DOI: 10.1039/C000283F

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