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Issue 20, 2010
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“Higher density does not mean higher stability” mystery of paracetamol finally unraveled

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Abstract

Topological analysis of the experimental electron density distribution functions for two polymorphs of paracetamol showed that strong H-bonds are responsible for the higher stability of crystal phase I, weak interactions for the higher density of phase II. This made it possible to finally resolve the contradiction between the relative stabilities and the densities of the two paracetamol polymorphs.

Graphical abstract: “Higher density does not mean higher stability” mystery of paracetamol finally unraveled

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Publication details

The article was received on 05 Jan 2010, accepted on 13 Apr 2010 and first published on 21 Apr 2010


Article type: Communication
DOI: 10.1039/B927429D
Citation: Chem. Commun., 2010,46, 3469-3471
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    “Higher density does not mean higher stability” mystery of paracetamol finally unraveled

    Y. V. Nelyubina, I. V. Glukhov, M. Yu. Antipin and K. A. Lyssenko, Chem. Commun., 2010, 46, 3469
    DOI: 10.1039/B927429D

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