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Issue 23, 2010
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Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

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Abstract

The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of 18F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.

Graphical abstract: Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

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Publication details

The article was received on 23 Dec 2009, accepted on 24 Mar 2010 and first published on 20 Apr 2010


Article type: Communication
DOI: 10.1039/B926980K
Citation: Chem. Commun., 2010,46, 4052-4054
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    Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes

    L. Carroll, R. Bejot, R. Hueting, R. King, P. Bonnitcha, S. Bayly, M. Christlieb, J. R. Dilworth, A. D. Gee, J. Declerck and V. Gouverneur, Chem. Commun., 2010, 46, 4052
    DOI: 10.1039/B926980K

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