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Issue 15, 2010
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Casuarine-6-O-α-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

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Abstract

Two novel casuarine-6-α-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.

Graphical abstract: Casuarine-6-O-α-d-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

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Publication details

The article was received on 16 Dec 2009, accepted on 10 Feb 2010 and first published on 23 Feb 2010


Article type: Communication
DOI: 10.1039/B926600C
Citation: Chem. Commun., 2010,46, 2629-2631
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    Casuarine-6-O-α-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

    F. Cardona, A. Goti, C. Parmeggiani, P. Parenti, M. Forcella, P. Fusi, L. Cipolla, S. M. Roberts, G. J. Davies and T. M. Gloster, Chem. Commun., 2010, 46, 2629
    DOI: 10.1039/B926600C

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