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Issue 26, 2010
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Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

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Abstract

Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.

Graphical abstract: Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

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Publication details

The article was received on 14 Dec 2009, accepted on 17 Mar 2010 and first published on 09 Apr 2010


Article type: Communication
DOI: 10.1039/B926359D
Citation: Chem. Commun., 2010,46, 4680-4682
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    Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

    H. Lee, D. S. Chan, F. Yang, H. Lam, S. Yan, C. Che, D. Ma and C. Leung, Chem. Commun., 2010, 46, 4680
    DOI: 10.1039/B926359D

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