Issue 15, 2010
From the journal:

Chemical Communications

Zinc(ii)-catalyzed Grignard additions to ketones with RMgBr and RMgI†

Manabu Hatano,a   Orie Ito,a   Shinji Suzukia  and  Kazuaki Ishihara*ab  

* Corresponding authors

a Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, Japan
E-mail: ishihara@cc.nagoya-u.ac.jp
Fax: +81-52-789-3331
Tel: +81-52-789-3222

b Japan Science and Technology Agency (JST), CREST, Furo-cho, Chikusa, Nagoya, Japan

Abstract

Highly efficient alkylations and arylations of ketones with Grignard reagents (RMgBr and RMgI) have been developed using catalytic ZnCl2, Me3SiCH2MgCl, and LiCl. Tertiary alcohols were obtained in high yields with high chemoselectivities, while minimizing undesired side products produced by reduction and enolization.

Graphical abstract: Zinc(ii)-catalyzed Grignard additions to ketones with RMgBr and RMgI

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Article information

DOI
https://doi.org/10.1039/B926243A
Article type
Communication
Submitted
11 Dec 2009
Accepted
19 Jan 2010
First published
09 Feb 2010

Chem. Commun., 2010,46, 2674-2676

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Zinc(II)-catalyzed Grignard additions to ketones with RMgBr and RMgI

M. Hatano, O. Ito, S. Suzuki and K. Ishihara, Chem. Commun., 2010, 46, 2674 DOI: 10.1039/B926243A

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