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Issue 13, 2010
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Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples

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Abstract

We report a sensitive method for selective detection of target metabolites from the central metabolic pathway by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS), in which the MS signal is enhanced by up to three orders of magnitude in the course of in situ enzymatic amplification.

Graphical abstract: Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples

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Publication details

The article was received on 02 Dec 2009, accepted on 08 Feb 2010 and first published on 25 Feb 2010


Article type: Communication
DOI: 10.1039/B925433A
Citation: Chem. Commun., 2010,46, 2212-2214
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    Mass spectrometric method incorporating enzymatic amplification for attomole-level analysis of target metabolites in biological samples

    P. L. Urban, A. Amantonico, S. R. Fagerer, P. Gehrig and R. Zenobi, Chem. Commun., 2010, 46, 2212
    DOI: 10.1039/B925433A

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