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Issue 14, 2010
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New xanthate-based radical cyclization onto alkynes

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Abstract

To bypass the failure of radical cyclization involving a xanthate transfer on alkynes, a new reductive cyclization strategy has been completed with the use of a stoichiometric amount of dilauroyl peroxide in isopropanol. When the starting xanthates are prepared via a Ugi 4-component reaction with propargylamine, exomethylene lactams are formed in good yields.

Graphical abstract: New xanthate-based radical cyclization onto alkynes

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Publication details

The article was received on 18 Nov 2009, accepted on 08 Jan 2010 and first published on 27 Jan 2010


Article type: Communication
DOI: 10.1039/B924207D
Citation: Chem. Commun., 2010,46, 2489-2491
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    New xanthate-based radical cyclization onto alkynes

    L. El Kaïm, L. Grimaud, L. D. Miranda, E. Vieu, M.-Angeles Cano-Herrera and K. Perez-Labrada, Chem. Commun., 2010, 46, 2489
    DOI: 10.1039/B924207D

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