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Issue 8, 2010
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Enzymatic activation of a matrix metalloproteinase inhibitor

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Abstract

Matrix metalloproteinase inhibitors (MMPi) possessing a glucose protecting group on the zinc-binding group (ZBG) show a dramatic increase in inhibitory activity upon cleavage by β-glucosidase.

Graphical abstract: Enzymatic activation of a matrix metalloproteinase inhibitor

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Publication details

The article was received on 05 Nov 2009, accepted on 20 Nov 2009 and first published on 18 Jan 2010


Article type: Communication
DOI: 10.1039/B923302D
Citation: Chem. Commun., 2010,46, 1241-1243
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    Enzymatic activation of a matrix metalloproteinase inhibitor

    J. L. Major Jourden and S. M. Cohen, Chem. Commun., 2010, 46, 1241
    DOI: 10.1039/B923302D

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