Chemical rescue of protein tyrosine phosphatase activity

Vincent L. Chen; Anthony C. Bishop

doi:10.1039/B919815F

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Chemical Communications

Issue 4, 2010

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Chemical rescue of protein tyrosine phosphatase activity

Vincent L. Chen and Anthony C. Bishop

Chem. Commun., 2010, 46, 637-639

DOI: 10.1039/B919815F
Received 23 Sep 2009, Accepted 04 Nov 2009
First published on the web 18 Nov 2009

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We report that the activity of a rationally engineered protein tyrosine phosphatase (PTP) mutant can be fully rescued by the addition of the biarsenical fluorescein derivative FlAsH, a compound that does not affect the activity of wild-type PTPs.

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Chemical Communications

Chemical rescue of protein tyrosine phosphatase activity

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