SERS aptasensor from nanorod–nanoparticle junction for protein detection

Yuling Wang; Kyuwan Lee; Joseph Irudayaraj

doi:10.1039/B919607B

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Chemical Communications

Issue 4, 2010

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SERS aptasensor from nanorod–nanoparticle junction for protein detection

Yuling Wang , Kyuwan Lee and Joseph Irudayaraj

Chem. Commun., 2010, 46, 613-615

DOI: 10.1039/B919607B
Received 21 Sep 2009, Accepted 04 Nov 2009
First published on the web 18 Nov 2009

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Abstract
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A multicomponent nanostructure comprising of gold nanorod–nanoparticle (AuNR–AuNP) composites was fabricated to detect thrombin at subnanomolar concentrations in diluted human blood serum. Simulation and experiments revealed that the strong electromagnetic coupling resonance at the nanorod–nanoparticle junction of these probes can be used to construct highly sensitive SERS aptasensors.

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The experimental details, additional TEM images ofAuNPs–AuNRs junctions, FDTD simulation and SERS spectra ofother Raman reporters for thrombin detection
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Chemical Communications

SERS aptasensor from nanorod–nanoparticle junction for protein detection

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