An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging

Mayca Onega; Juozas Domarkas; Hai Deng; Lutz F. Schweiger; Timothy A. D. Smith; Andrew E. Welch; Christophe Plisson; Antony D. Gee; David O’Hagan

doi:10.1039/B919364B

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Chemical Communications

Issue 1, 2010

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An enzymatic route to 5-deoxy-5-[¹⁸F]fluoro-D-ribose, a [¹⁸F]-fluorinated sugar for PET imaging

Mayca Onega , Juozas Domarkas , Hai Deng , Lutz F. Schweiger , Timothy A. D. Smith , Andrew E. Welch , Christophe Plisson , Antony D. Gee and David O’Hagan

Chem. Commun., 2010, 46, 139-141

DOI: 10.1039/B919364B
Received 17 Sep 2009, Accepted 20 Oct 2009
First published on the web 10 Nov 2009

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An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[¹⁸F]fluororibose, a novel [¹⁸F]-fluorinated sugar suitable for positron emission tomography (PET) applications.

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Articles By

Mayca Onega
Juozas Domarkas
Hai Deng
Lutz F. Schweiger
Timothy A. D. Smith
Andrew E. Welch
Christophe Plisson
Antony D. Gee
David O’Hagan

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Chemical Communications

An enzymatic route to 5-deoxy-5-[¹⁸F]fluoro-D-ribose, a [¹⁸F]-fluorinated sugar for PET imaging

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