Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes

Alexandro Membrino; Manikandan Paramasivam; Susanna Cogoi; Jawad Alzeer; Nathan W. Luedtke; Luigi E. Xodo

doi:10.1039/B918964E

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Chemical Communications

Issue 4, 2010

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Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes

Alexandro Membrino , Manikandan Paramasivam , Susanna Cogoi , Jawad Alzeer , Nathan W. Luedtke and Luigi E. Xodo

Chem. Commun., 2010, 46, 625-627

DOI: 10.1039/B918964E
Received 14 Sep 2009, Accepted 23 Oct 2009
First published on the web 20 Nov 2009

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Abstract
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Guanidino-modified phthalocyanines are evaluated in vitro (polymerase-stop assays and FRET) and in cultured cells as G4-DNA ligands and modulators of gene transcription.

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Experimental procedures, including synthesis, polymerase stopassays, FRET and CD data are available free of charge via the Internet at http://pubs.acs.org
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Alexandro Membrino
Manikandan Paramasivam
Susanna Cogoi
Jawad Alzeer
Nathan W. Luedtke
Luigi E. Xodo

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Chemical Communications

Cellular uptake and binding of guanidine-modified phthalocyanines to KRAS/HRAS G-quadruplexes

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