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Issue 10, 2010
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Programing the formation of DNA and PNA quadruplexes by π–π-stacking interactions

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Abstract

Guanine (G) rich G4T4G4 DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5′-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by π–π-stacking interaction exerted by the 5′-residues.

Graphical abstract: Programing the formation of DNA and PNA quadruplexes by π–π-stacking interactions

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Publication details

The article was received on 04 Aug 2009, accepted on 17 Dec 2009 and first published on 13 Jan 2010


Article type: Communication
DOI: 10.1039/B915955J
Citation: Chem. Commun., 2010,46, 1685-1687
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    Programing the formation of DNA and PNA quadruplexes by π–π-stacking interactions

    S. Saha, J. Cai, D. Eiler and A. D. Hamilton, Chem. Commun., 2010, 46, 1685
    DOI: 10.1039/B915955J

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